On a brand new ROG STRIX X670E-E GAMING WIFI motherboard paired with a Ryzen 5950x CPU, and a G.SKILL Ripjaws S5 Black 64GB (2x32GB) DDR5 6000MHz CL30 Dual Channel Kit, after the update to the lastest BIOS v2506, date 2024/11/05 the board would fail to enter Windows 11 and hang with 99 Error code on the Qcode LED panel.

The QCode panel lists 99 as Super IO Initialization:

The solution for this was to disconnect the 2 USB hubs connected to the PC. One USB hub has 10 ports and the other has 5. The ports are fully populated, so the problem could be the power draw or compatibility, even if the USB hubs have power supplied by 12V adapters.